EFFECTS OF PHALLOIDIN IN LIVER-CELLS - BINDING, MORPHOLOGICAL-CHANGES, AND ELIMINATION

  • 1 January 1978
    • journal article
    • research article
    • Vol. 17  (1) , 73-83
Abstract
The uptake, binding and elimination of phalloidin in liver is compared in adult (180-240 g) and baby (17-19 days old) rats in vivo and in vitro. In both groups there is no relation between the concentration of the poison in the liver and the toxicity. Although baby rats show a significantly higher tolerance against phalloidin than the adult animals, the concentration of the poison in the liver of baby rats is higher, and the elimination is significantly slower than in adult rats. The very tight binding and concentration of phalloidin in the liver is explained by an extremely low dissociation constant. Furthermore, the morphological differences between the poisoning of the liver cells in the entire organ and of isolated liver cells are discussed.

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