Griseochelin, a novel carboxylic acid antibiotic from Streptomyces griseus.

1 January 1984

journal article
Published by Japan Antibiotics Research Association in The Journal of Antibiotics

Vol. 37 (8) , 836-846
https://doi.org/10.7164/antibiotics.37.836

Abstract

Griseochelin, C₃₃H₆₀O₇, isolated from an asporogenous strain of Streptomyces griseus represents a novel carboxylic acid antibiotic. The metabolite, which is active against Gram-positive bacteria, forms water-insoluble salts with mono- and divalent cations and binds alkaline-earth metal ions specifically in 2: 1 (x₂M) stoichiometry. Detailed spectral (IR, MS and NMR) studies provide full characterization of its constitution featuring a carboxylic acid function, a substituted tetrahydropyran ring, an allylic OH group which are accomodated within a tetrahydroxylated-octamethyl-C₂₅ diene backbone.

Keywords

SALTS
CARBOXYLIC ACID
STREPTOMYCES
GRISEOCHELIN
GRISEUS
TETRAHYDROXYLATED
TETRAHYDROPYRAN
METABOLITE
CONSTITUTION

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