Studies on Calcium Transport and Calcium-dependent Adenosine Triphosphatase Activity of Erythrocyte Membranes in Hereditary Spherocytosis

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Abstract
Evidence was recently presented of a relative deficiency of Ca2+-dependent ATP, activity of erythrocyte membranes obtained from patients with hereditary spherocytosis. Ca efflux from intact erythrocytes of patients with hereditary spherocytosis, as well as erythrocyte Ca concentrations were measured but both parameters were normal. Ca2+-dependent ATP activity, as well as Ca2+-dependent membrane phosphorylation was not deficient in erythrocyte membranes from subjects with hereditary spherocytosis. These studies do not support the postulate that an accumulation of Ca affects the deformability of erythrocytes and their subsequent destruction in the spleen.