A convenient synthesis of toxoflavins, toxoflavin 4-oxides and 1-demethyltoxoflavins.
- 1 January 1975
- journal article
- research article
- Published by Pharmaceutical Society of Japan in CHEMICAL & PHARMACEUTICAL BULLETIN
- Vol. 23 (9) , 2001-2009
- https://doi.org/10.1248/cpb.23.2001
Abstract
A convenient synthesis of toxoflavins and toxoflavin 4-oxides, which consists of the nitrosative cyclization of the aldehyde hydrazones of 3-methyl-6-(1-methylhydrazino)uracil, is described. Both toxoflavins and toxaflavin 4-oxides gave the corresponding 1-dimethyltoxoflavins (8-demethylfervenulins) by treatment with nucleophiles such as dimethylformamide, diemthylacetamide and acetic acid. The preparation of some 4,8-dihydrotoxoflavin derivatives is described.This publication has 0 references indexed in Scilit: