Primary structure of the gamma-carboxyglutamic acid-containing protein from bovine bone.
- 1 October 1976
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 73 (10) , 3374-3375
- https://doi.org/10.1073/pnas.73.10.3374
Abstract
The amino-acid sequence of the .gamma.-carboxyglutamic acid-containing protein of bovine bone is presented. The sequence of 43 of the 49 residues was determined automatically on the intact protein and on a tryptic peptide. The remainder was determined by conventional procedures on tryptic and chymotryptic peptides. Residue 9 in the sequence was identified as 4-hydroxyproline. The protein contains 3 .gamma.-carboxyglutamic acid residues, which are located at positions 17, 21 and 24. The role of these unusual amino acids in the binding interaction between the protein and hydroxyapatite crystals is discussed.This publication has 14 references indexed in Scilit:
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