Outcomes in Hypertensive Black and Nonblack Patients Treated With Chlorthalidone, Amlodipine, and Lisinopril

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Abstract
Cardiovascular disease (CVD) has become the leading cause of morbidity and mortality worldwide, and elevated blood pressure (BP) is a leading contributor to this phenomenon.1,2 The population of blacks with hypertension has the highest morbidity and mortality from hypertension of any population group in the United States and is among the highest in the world.3,4 Mortality related to hypertension and the risk of end-stage renal disease (ESRD), coronary heart disease (CHD), heart failure (HF), and stroke are increased in the black compared with the white population in the United States.4,5 While the benefits of lowering elevated BP in reducing cardiovascular morbidity and mortality are well established, until recently well-controlled studies comparing different classes of antihypertensive agents for reducing cardiovascular complications of hypertension were not available.

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