Inhibitory Effects of Licochalcone A Isolated fromGlycyrrhiza inflataRoot on Inflammatory Ear Edema and Tumour Promotion in Mice
- 1 June 1991
- journal article
- research article
- Published by Georg Thieme Verlag KG in Planta Medica
- Vol. 57 (03) , 221-224
- https://doi.org/10.1055/s-2006-960078
Abstract
Licochalcone A, 3-α,α-dimethylallyl-4,4′-dihydroxy-6-methoxychalcone, from the root of Glycyrrhiza inflata Beta (Leguminosae) (Xin-jiang liquorice) showed anti-inflammatory action towards mouse ear edema induced by arachidonic acid (AA) and 12-O-tetradecanoylphorbol 13-acetate (TPA) by topical application. Anti-tumour promoting action of licochalcone A was also observed in vivo for mouse skin papilloma initiated by dimethylbenz[a]anthracene (DMBA) and promoted by TPA. It inhibited in vitro 32Pi-incorporation to phospholipids in HeLa cells promoted by TPA. A competitive interaction of licochalcone A with the TPA-receptors in the cell membrane has been suggested.Keywords
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