Comparative uptake, vascular transport, and cellular internalization of aflatoxin-B1 and benzo(a)pyrene
- 1 June 1990
- journal article
- research article
- Published by Springer Nature in Archives of Toxicology
- Vol. 64 (4) , 285-290
- https://doi.org/10.1007/bf01972988
Abstract
Studies of the uptake of benzo(a)pyrene (BaP) and aflatoxin-B1 (AFB1) after gastric instillation showed that BaP was absorbed via the intestinal lymphatic drainage and transported to the vascular circulation sequestered within lipoproteins in thoracic duct lymph, while AFB1 was absorbed with water soluble compounds into the gastrointestinal venous drainage and was not transported in association with lipoproteins. BaP was taken up into plasma lipoproteins over a broad concentration range, while AFB1 was not sequestered within lipoproteins over the same concentration range. Low density lipoproteins (LDL) facilitated BaP uptake into fibroblasts and impeded BaP uptake into hepatocytes. High density lipoproteins (HDL) facilitated BaP uptake into hepatocytes and impeded BaP uptake into fibroblasts. The uptake of AFB1 into either fibroblasts or hepatocytes was not affected by lipoproteins.This publication has 40 references indexed in Scilit:
- Metabolism, DNA binding, and cytotoxicity of aflatoxin B1 in tracheal explants from Syrian hamsterToxicology, 1984
- Toxicity of aflatoxin B1 in rat and mouse hepatocytes in vivo and in vitroToxicology, 1984
- Metabolic basis of the species difference to aflatoxin B1 induced hepatotoxicityBiochemical and Biophysical Research Communications, 1983
- Recycling receptors: The round-trip itinerary of migrant membrane proteinsCell, 1983
- The hepatocyte primary culture/DNA repair assay using mouse or hamster hepatocytesEnvironmental Mutagenesis, 1983
- Binding of benzo[a]pyrene and intracellular transport of a bound electrophilic benzo[a]pyrene metabolite by lipoproteinsCarcinogenesis: Integrative Cancer Research, 1982
- Butylate hydroxytoluene pretreatment protects against cytotoxicity and reduces covalent binding of aflatoxin B1 in primary hepatocyte culturesToxicology and Applied Pharmacology, 1981
- Interaction of insecticides with human plasma lipoproteinsChemico-Biological Interactions, 1981
- Binding of the chemical carcinogen, p‐dimethylaminoazobenzene, by human plasma low density lipoproteinsFEBS Letters, 1979
- The binding of [3H] dolichol by plasma high density lipoproteinsBiochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1977