X-radiation and alkylating agents as possible "trigger" mechanisms in the autoimmune complications of malignant lymphophroliferative disease.

  • 1 January 1966
    • journal article
    • Vol. 1  (1) , 3-11
Abstract
One hundred patients with lymphoproliferative disease were reviewed. Seven of these patients were found to develop an autoimmune complication following the use of radiation or radiomimetic drug. The literature suggesting that radiation can enhance as well as suppress the autoimmune response is summarized, and the possibility that therapy can trigger autoimmunity in these patients is emphasized.