Ketten‐substituierte Lipide als Substrate für Phospholipase A2
- 1 September 1989
- journal article
- zuschrift
- Published by Wiley in Angewandte Chemie
- Vol. 101 (9) , 1277-1278
- https://doi.org/10.1002/ange.19891010926
Abstract
Stabilere wirkstofftragende Liposomen und Substanzen zur Steuerung der Prostaglandin‐Konzentration könnten aus der Beobachtung resultieren, daß Phospholipide wie 1 mit sperrigen Alkylsubstituenten in der ersten Hälfte der Fettsäurereste sehr viel schlechter durch Phospholipase A2 hydrolysiert werden als Distearoylphosphatidylcholin selbst. magnified imageKeywords
This publication has 15 references indexed in Scilit:
- Thermotropic properties of synthetic chain-substituted phosphatidylcholines: effect of substituent size, polarity, number, and location on molecular packing in bilayersJournal of the American Chemical Society, 1988
- Structure-activity relationship of synthetic branched-chain distearoylglycerol (distearin) as protein kinase C activatorsBiochemistry, 1988
- Chain-substituted lipids in monolayer films. A study of molecular packingJournal of the American Chemical Society, 1988
- Phospholipase A2 inhibition and modification by manoalogueJournal of the American Chemical Society, 1988
- Synthetic branched-chain analogs of distearoylphosphatidylcholine: structure-activity relationship in inhibiting and activating protein kinase CBiochemistry, 1988
- Fast atom bombardment mass spectrometry of branched‐chain phosphatidylcholinesJournal of Mass Spectrometry, 1988
- Protein Crystallography and Computer Graphics—toward Rational Drug DesignAngewandte Chemie International Edition in English, 1986
- Methyl branching in short-chain lecithins: are both chains important for effective phospholipase A2 activityBiochemistry, 1985
- Syntheses of enzyme-inhibitory phospholipid analogs. Stereospecific synthesis of 2-amidophosphatidylcholines and related derivativesThe Journal of Organic Chemistry, 1982
- Activity of phospholipase A2 in reversed micelles of phosphatidylcholine in diethyl ether. Effect of water and cationsBiochemistry, 1974