Polymorphic acetylation and aminopyrine demethylation in Gilbert's syndrome

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Abstract
Polymorphic acetylation was investigated in twenty‐seven patients with Gilbert's syndrome using the sulphadimidine test. Whereas the finding of 51% slow acetylators in seventy‐eight control persons agreed well with the expected frequency in a continental European population, the prevalence of slow acetylators in Gilbert's syndrome was increased to 78% (P, Woolfs G‐test). After oral administration of 14C‐aminopyrine there was no significant difference between seventeen patients with Gilbert's syndrome and twenty‐seven normal controls in total plasma clearance of aminopyrine (280 ± SD 100 and 270 ± 60 ml/min) and in the disappearance curve of 14CO2 in breath (0.23 ± 0.04 and 0.22 ± 0.03 h‐1 respectively). Thus, whereas aminopyrine metabolism appears unaffected in the examined patients, the data documents a new association between slow acetylator status and Gilbert's syndrome.