Control of tumor growth in mice by thoracic duct drainage: Relationship to blocking factor in lymph

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Abstract
Tumor‐specific blocking factors were detected by the macrophage migration inhibition technique, in thoracic duct lymph collected 24 to 48 h after transplantation of two methylcholanthrene‐induced tumors into mice. Drainage of lymph in this period, with replacement of the cells, inhibited subsequent tumor growth. Blocking factor was not found in lymph from mice with a third tumor, when examined at the same stage, and thoracic duct drainage did not affect tumor growth in this instance. The results indicate that blocking factor has a function in vivo and that decreasing its concentration in a tumor‐bearing host at a critical stage can suppress tumor growth.