INCREASED METABOLISM ONLY ONE FACTOR IN THE PRODUCTION AND MAINTENANCE OF THE HYPERGLYCEMIA AND GLYCOSURIA IN EXPERIMENTAL HYPERTHYROIDISM

Publisher Website
Google Scholar
Abstract
Large doses of thyroid extract do not produce a hyperglycemia and glycosuria in normal dogs. However, in the series of 6 dogs which have had the major portion of their pancreas removed (19/20) with the factor of safety reduced to a minimum, it was effective in the production of a permanent hyperglycemia and glycosuria (diabetes). The greater hyperpyrexia which accompanies the subcutaneous injection of sodium nu-cleinate produces a mild hyperglycemia and glycosuria in normal dogs. In the series of 4 partially pancreatecto-mized dogs sodium nucleinate did not cause as marked and persistent a hyperglycemia and glycosuria as did thyroid feeding. The influence of the thyroid seems to be not solely through its effect on basal metabolism, but possibly through some toxic effect of thyroxin exerted on the islet tissue of the pancreas. In this sense (toxic action of the thyroid hormone), one might speak of an antagonism between the pancreas and the thyroid.

This publication has 0 references indexed in Scilit: