The Quinidine-Digoxin Interaction

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Abstract
In 1978, three groups independently described a drug interaction between quinidine and digoxin: When quinidine is given to patients taking digoxin, the serum digoxin concentration increases.1 2 3 These reports have raised many interesting and important questions and a flurry of investigation. Two recent articles in the Journal provide some insight into the mechanism of this interaction.4 , 5 The purpose of this editorial is to review the information currently available on the digoxin-quinidine interaction and to discuss its clinical implications.What is the prevalence of the interaction? Although the number of patients studied is still less than 100, we can be reasonably certain . . .

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