Mechanisms of polymer degradation in implantable devices. 2. Poly(DL‐lactic acid)
- 1 November 1993
- journal article
- research article
- Published by Wiley in Journal of Biomedical Materials Research
- Vol. 27 (11) , 1409-1418
- https://doi.org/10.1002/jbm.820271108
Abstract
The hydrolytic degradation of poly(DL-lactic acid) in an aqueous environment in which hydroxyl radicals have been generated has been investigated. Different methods (gel permeation chromatography, differential scanning calorimetry, and scanning electron microscopy) were employed to study the mechanisms of degradation of this amorphous physiologically absorbable polymer. The data indicated that the hydroxyl radical is likely to be a significant factor in the degradation of this polymer. © 1993 John Wiley & Sons, Inc.Keywords
This publication has 24 references indexed in Scilit:
- Stability of performances of vascular prostheses retrospective study of 22 cases of human implanted prosthesesJournal of Biomedical Materials Research, 1988
- Biostability of Polyurethane Elastomers: A Critical ReviewJournal of Biomaterials Applications, 1988
- Polymers for biodegradable medical devicesBiomaterials, 1987
- On the biodegradation of poly-β-hydroxybutyrate (PHB) homopolymer and poly-β-hydroxybutyrate-hydroxyvalerate copolymersBiomaterials, 1987
- Biomedical polymers from chiral lactides and functional lactones: Properties and applicationsMakromolekulare Chemie. Macromolecular Symposia, 1986
- Autooxidative Degradation of Implanted Polyether Polyurethane DevicesJournal of Biomaterials Applications, 1986
- Aliphatic polyesters II. The degradation of poly (DL-lactide), poly (ε-caprolactone), and their copolymers in vivoBiomaterials, 1981
- Active Oxygen Species and the Functions of Phagocytic LeukocytesAnnual Review of Biochemistry, 1980
- Subcutaneous implants of polypropylene filamentsJournal of Biomedical Materials Research, 1976
- The foreign body reaction—an experimental protocolJournal of Biomedical Materials Research, 1974