The inefficiency of incisions of ecteinascidin 743–DNA adducts by the UvrABC nuclease and the unique structural feature of the DNA adducts can be used to explain the repair-dependent toxicities of this antitumor agent
Open Access
- 1 November 2001
- journal article
- research article
- Published by Elsevier in Chemistry & Biology
- Vol. 8 (11) , 1033-1049
- https://doi.org/10.1016/s1074-5521(01)00071-0
Abstract
No abstract availableKeywords
This publication has 38 references indexed in Scilit:
- Phase I and Pharmacokinetic Study of Ecteinascidin-743, a New Marine Compound, Administered as a 24-hour Continuous Infusion in Patients With Solid TumorsJournal of Clinical Oncology, 2001
- NMR-Based Model of an Ecteinascidin 743−DNA AdductJournal of the American Chemical Society, 1997
- Ecteinascidins: Putative Biosynthetic Precursors and Absolute StereochemistryJournal of the American Chemical Society, 1996
- Progress in the acquisition of new marine-derived anticancer compounds: development of ecteinascidin-743 (ET-743)Drugs of the Future, 1996
- DNA sequence selectivities in the covalent bonding of antibiotic saframycins Mx1, Mx3, A, and S deduced from MPE.cntdot.iron(II) footprinting and exonuclease III stop assaysBiochemistry, 1992
- Computer simulation of the binding of saframycin A to d(GATGCATC)2Journal of Medicinal Chemistry, 1991
- Ecteinascidins 729, 743, 745, 759A, 759B, and 770: potent antitumor agents from the Caribbean tunicate Ecteinascidia turbinataThe Journal of Organic Chemistry, 1990
- Mode of action of saframycin antitumor antibiotics: sequence selectivities in the covalent binding of saframycins A and S to deoxyribonucleic acidChemical Research in Toxicology, 1990
- The in vitro interaction of naphthyridinomycin with deoxyribonucleic acidsChemico-Biological Interactions, 1985
- Proposed structure of the anthramycin–DNA adductNature, 1979