SPECIES AND STRAIN DIFFERENCES IN SENSITIVITY TO TOXOPLASMA INFECTION AMONG LABORATORY RODENTS
- 1 January 1983
- journal article
- research article
- Published by Editorial Committee of Japanese Journal of Infectious Diseases, National Institute of Infectious Dis in Japanese Journal of Medical Science and Biology
- Vol. 36 (6) , 343-346
- https://doi.org/10.7883/yoken1952.36.343
Abstract
Different susceptibilities to Toxoplasma infection were shown among various inbred and outbred laboratory rodents. On the basis of several criteria, the animals can be divided into three groups: (i) highly sensitive (S) mice, Syrian hamsters and Chinese hamsters; (ii) moderately sensitive (M) Mongolian gerbils and mastomyses; and (iii) resistant (R) rats and Korean striped field mice. S and M hosts supported intraperitoneal growth of the parasites and died of acute infection. M hosts showed prolonged time to death and low fatality as compared with S hosts. Some R hosts died only when they had received an extremely large size of inoculum, accompanying poor intraperitoneal proliferation of the parasite. WM/Ms and WKY rats markedly resisted the infection. These hosts were considered to be useful models for studying infection of and immunity to toxoplasmosis.Keywords
This publication has 1 reference indexed in Scilit:
- Production and Properties of Immune Interferon from Spleen Cell Cultures ofToxoplasma-Infected MiceMicrobiology and Immunology, 1980