Coronavirus infection of the central nervous system: host–virus stand-off
Top Cited Papers
- 1 February 2006
- journal article
- review article
- Published by Springer Nature in Nature Reviews Microbiology
- Vol. 4 (2) , 121-132
- https://doi.org/10.1038/nrmicro1343
Abstract
Several viruses infect the mammalian central nervous system (CNS), some with devastating consequences, others resulting in chronic or persistent infections associated with little or no overt pathology. Coronavirus infection of the murine CNS illustrates the contributions of both the innate immune response and specific host effector mechanisms that control virus replication in distinct CNS cell types. Despite T-cell-mediated control of acute virus infection, host regulatory mechanisms, probably designed to protect CNS integrity, contribute to the failure to eliminate virus. Distinct from cytolytic effector mechanisms expressed during acute infection, non-lytic humoral immunity prevails in suppressing infectious virus during persistence.Keywords
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