Results of coronary artery surgery in patients with poor left ventricular function (CASS).

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Abstract
Four hundred twenty medically treated and 231 surgically treated patients (coronary graft plus myocardial surgery in 30%) who had severe left ventricular dysfunction manifest by an ejection fraction below 0.36 and markedly abnormal wall motion were identified. Compared with medically treated patients, those treated surgically had more severe angina (56.7 vs. 29.0% class III or IV; P < 0.001), less heart failure as predominant symptom (11.1 vs. 18.8%; P < 0.003), more severe coronary disease (66.7 vs. 50.2% 3-vessel disease; P < 0.001), a greater concentration of left main coronary artery lesions > 70% (12.6 vs. 3.8%: P < 0.001), and a greater estimated extent of jeopardized myocardium (P < 0.001). Multivariate regression analysis of survival, which adjusts for the above covariates, showed that surgical treatment prolonged survival (P < 0.05), although it ranked below severity of heart failure symptoms, age, ejection fraction and left main stenosis > 70% in determining prognosis. Surgical benefit was most apparent for patients with ejection fractions below 0.26 who had a 43% 5 yr survival with medical treatment vs. 63% with surgery. Surgically treated patients experienced substantial symptomatic benefit compared with medically treated patients if their presenting symptoms were predominantly angina; however, there was no relief of symptoms caused primarily by heart failure. Patients with predominantly ischemic pain symptoms, despite poor left ventricular function, apparently benefit from surgery; however, operative mortality in this high-risk subset must equal or better the 6.9% obtained in this study.