G‐protein‐coupled receptors: past, present and future
Top Cited Papers
- 1 January 2006
- journal article
- review article
- Published by Wiley in British Journal of Pharmacology
- Vol. 147 (S1) , S27-S37
- https://doi.org/10.1038/sj.bjp.0706455
Abstract
The G‐protein‐coupled receptor (GPCR) family represents the largest and most versatile group of cell surface receptors. Drugs active at these receptors have therapeutic actions across a wide range of human diseases ranging from allergic rhinitis to pain, hypertension and schizophrenia. This review provides a brief historical overview of the properties and signalling characteristics of this important family of receptors.British Journal of Pharmacology (2006) 147, S27–S37. doi:10.1038/sj.bjp.0706455Keywords
This publication has 72 references indexed in Scilit:
- Paul Ehrlich: Magister MundiNature Reviews Drug Discovery, 2004
- Constitutive activity of receptors coupled to guanine nucleotide regulatory proteinsPublished by Elsevier ,2002
- Pharmacological characterization of CGP 12177 at the human β2‐adrenoceptorBritish Journal of Pharmacology, 2002
- Coordinated Agonist Regulation of Receptor and G Protein Palmitoylation and Functional Rescue of Palmitoylation-deficient Mutants of the G Protein G11α following Fusion to the α1b-AdrenoreceptorPublished by Elsevier ,2001
- Stimulus-dependent Phosphorylation of G-protein-coupled Receptors by Casein Kinase 1αJournal of Biological Chemistry, 1997
- Enhanced Myocardial Function in Transgenic Mice Overexpressing the β 2 -Adrenergic ReceptorScience, 1994
- Cloning of the gene and cDNA for mammalian β-adrenergic receptor and homology with rhodopsinNature, 1986
- Inositol Phospholipid Hydrolysis in Rat Cerebral Cortical Slices: I. Receptor CharacterisationJournal of Neurochemistry, 1984
- Colchicine potentiates β-adrenoreceptor-stimulated cyclic AMP in lymphoma cells by an action distal to the receptorNature, 1978
- The uptake of atropine and related drugs by intestinal smooth muscle of the guinea-pig in relation to acetylcholine receptorsProceedings of the Royal Society of London. B. Biological Sciences, 1965