Type III secretion system cluster 3 is required for maximal virulence ofBurkholderia pseudomalleiin a hamster infection model
Open Access
- 1 January 2005
- journal article
- Published by Oxford University Press (OUP) in FEMS Microbiology Letters
- Vol. 242 (1) , 101-108
- https://doi.org/10.1016/j.femsle.2004.10.045
Abstract
Burkholderia pseudomallei, the etiological agent of melioidosis, is an animal pathogen capable of inducing a highly fatal septicemia. B. pseudomallei possesses three type III secretion system (TTSS) clusters, two of which (TTSS1 and TTSS2) are homologous to the TTSS of the plant pathogen Ralstonia solanacearum, and one (TTSS3) is homologous to the Salmonella SPI-1 mammalian pathogenicity island. We have demonstrated that TTSS3 is required for the full virulence of B. pseudomallei in a hamster model of infection. We have also examined the virulence of B. pseudomallei mutants deficient in several putative TTSS3 effector molecules, and found no significant attenuation of B. pseudomallei virulence in the hamster model.Keywords
This publication has 27 references indexed in Scilit:
- Distribution of type III secretion gene clusters in Burkholderia pseudomallei, B. thailandensis and B. malleiJournal of Medical Microbiology, 2002
- A second type III secretion system in Burkholderia pseudomallei: who is the real culprit?Microbiology, 2001
- Detection of Bacterial Virulence Genes by Subtractive Hybridization: Identification of Capsular Polysaccharide of Burkholderia pseudomallei as a Major Virulence DeterminantInfection and Immunity, 2001
- Sequencing and characterization of a novel serine metalloprotease from Burkholderia pseudomalleiFEMS Microbiology Letters, 2000
- Endemic Melioidosis in Tropical Northern Australia: A 10‐Year Prospective Study and Review of the LiteratureClinical Infectious Diseases, 2000
- The secreted effector protein of Salmonella dublin, SopA, is translocated into eukaryotic cells and influences the induction of enteritisCellular Microbiology, 2000
- Salmonellainteractions with host cells:in vitroto in vivoPhilosophical Transactions Of The Royal Society B-Biological Sciences, 2000
- Evidence for the presence in Burkholderia pseudomallei of a type III secretion system-associated gene clusterJournal of Medical Microbiology, 1999
- The type II O‐antigenic polysaccharide moiety of Burkholderia pseudomallei lipopolysaccharide is required for serum resistance and virulenceMolecular Microbiology, 1998
- Purification and characterization of a protease from Pseudomonas pseudomalleiCanadian Journal of Microbiology, 1994