Distribution in Piglets after Administration of 14 C-L-Proline as Studied by Whole Body Autoradiography and Impulse Counting

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Abstract
Distribution on intramuscularly administered 14C-L-proline in neonatal piglets was studied by whole body autoradiography and impulse counting technique. A high and specific uptake of radioactivity was found in the metaphysis, the periosteal layers and the articular areas of the bones. The superficial part of the teeth showed a pronounced accumulation of 14C. The localization of the label to the hard tissues presumably represents the synthesis of matricial proteins, i. e., collagens. The content of 14C in the liver indicates protein synthesis or intermediate metabolism of proline rather than excretion of the amino acid. The kidneys seem to be the major excretion route of intramuscularly injected proline and its metabolites. The marked uptake in the pancreas and the salivary glands is supposed to be associated with rapid synthesis of proteins of the pancreatic juice and the saliva. The potential relation between skeletal disorders and incomplete formation of collagen is discussed. Copyright © 1975. American Society of Animal Science . Copyright 1975 by American Society of Animal Science.

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