Computer Simulation of Cascade Filtration Procedures*

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Abstract
Cascade filtration is one of several techniques for processing separated plasma in order to remove pathogenic protein fractions. This is accomplished by a secondary membrane filter arranged in series with a plasma separating device.To provide a re-infusable filtrate of appropriate protein composition it is possible to adjust the performance data of a given secondary membrane over a wide range by appropriately manipulating the operating conditions of the filter.Using mass transport equations and single-pool kinetics, a computer model was established for simulating the effect on patient’s plasma protein concentrations of different filtration protocols and membranes with different sieving characteristics. To the user, this model offers a possibility of optimizing therapeutic protocols, and to the membrane producer a way of extrapolating a given membrane’s laboratory performance profile to the approximate performance in the actual clinical situation.

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