The Mast Cell — A Fascinating Riddle

Abstract
The mast cell is a connective-tissue cell widely distributed throughout the body and is found in surprisingly large numbers in certain organs. The biologic function of this curious cell, first described by Ehrlich in 18771 as a well fed* connective-tissue cell, has begun to be understood in the past 10 to 15 years.Allergic rhinitis, allergic asthma and urticaria are the most common immunologic diseases, affecting more than 20 per cent of the American population. After exploring the basic mechanisms underlying these diseases for more than 75 years, it is now clear that interactions between allergens and IgE adherent to . . .

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