Temporal Lobe Seizures in the Monkey

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Abstract
The postulate that a suppressor mechanism might play an important role in the production of psychomotor seizure suggested the research for suppressor regions in the temporal lobe. These were found in form of points in the superior gyrus of the temporal lobe. In order to study possible seizures elicited from such suppressor points, electrodes were embedded and after recovery, the suppressor region was stimulated by electric current and spontaneous seizures were produced by application of epileptogenic substances over the temporal suppressor region. Induced seizures in both cases were almost identical: The animal suddenly ceased all voluntary activity, lost its usual defense reflexes and became quiet and unresponsive even to aggressive actions. These attacks last a few minutes but spontaneous attacks tend to occur in series. The ecg shows characteristic changes during such attacks. Usually there is random spiking activity from the lead over the involved temporal lobe. Suddenly this spiking activity increases and the other leads begin to show suppression of their electrical activity. In 2 - 4 minutes there is marked suppression, and it is during this period that the above described seizures are noticed.

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