The excretion of kynurenine and 3-hydroxykynurenine by man

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Abstract
In a large proportion of cases the febrile human excretes hydroxykynurenine. This excretion is, in particular, unrelated to tuberculosis or diabetes. It is attributed to a high rate of breakdown of body protein. In states associated with weight loss but not accompanied by fever, hydroxykynurenine excretion could not be detected. The normal human taking an excess of tryptophane by mouth excretes much kynurenine, but no, or negligible, hydroxykynurenine. Possible reasons for this difference in excretory patterns are discussed.