Effect of Fluid Volume on Gastric Emptying and Gastro-intestinal Absorption of Thiopental-Na and Aminopyrine in Mouse

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Abstract
The influence of coadministered fluid volume on pharmacological response, gastrointestinal absorption and gastric emptying of thiopental sodium and aminopyrine after oral administration was examined in mice. When the coadministered fluid volume increased from 4-20 ml/kg, the hypnotic effect of thiopental sodium and analgetic effect of aminopyrine increased in proportion to fluid volume. The remaining percentages of these drugs in gastrointestine were also reduced with an increase in fluid volume. These drugs in the stomach after oral administration were transferred to the small intestine at a relatively fast rate in the initial stage and then gradually evacuated according to exponential process. This fast gastric emptying in the initial stage was accelerated in proportion to fluid volume, however, the gastric emptying rate evacuated exponentially with time was not influenced by the increase of fluid volume. It was defined that the acceleration of gastric emptying in the initial stage due to the increase of fluid volume enhanced the absorption rate of drugs in the small intestine. Great care should be taken for the fluid volume accompanying the extract of pharmacological response of drug by use of a small animal.