Pyrrolizidine alkaloid biosynthesis. Incorporation of 14C-labelled precursors into retronecine
- 1 January 1981
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Perkin Transactions 1
- No. 12,p. 3083-3086
- https://doi.org/10.1039/p19810003083
Abstract
The biosynthesis of the retronecine (3) portion of the pyrrolizidine alkaloid retrorsine (1) present in Senecio isatideus plants has been studied with the aid of 14C-labelled precursors. Putrescine (5), spermidine (6), and spermine (7), are the most efficient precursors of the pyrrolizidine ring. Degradations of labelled retronecine samples indicated that two molecules of each precursor are utilised, and that from these two molecules, a symmetrical intermediate of the type C4–N–C4 is formed and converted into retronecine.This publication has 0 references indexed in Scilit: