Vertebrate collagenase inhibitor. I. Tripeptidyl hydroxamic acids.
- 1 January 1990
- journal article
- research article
- Published by Pharmaceutical Society of Japan in CHEMICAL & PHARMACEUTICAL BULLETIN
- Vol. 38 (4) , 1007-1011
- https://doi.org/10.1248/cpb.38.1007
Abstract
A series of tripeptidyl analogues carrying hydroxamic acid residue at the C-terminus of the molecule were synthesized, and their inhibitory activities against vertebrate collagenase and other metalloenzymes including bacterial collagense were examined. Both Z-Pro-Leu-Ala-NHOH and z-Pro-D-Leu-D-Ala-NHOH showed highly specific and potent inhibitory activity against tadpole and human skin collagenases with an IC50 of 10-6 M order.This publication has 13 references indexed in Scilit:
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