ESTROGEN PROFILES OF PREMENOPAUSAL WOMEN WITH BREAST-CANCER

  • 1 January 1978
    • journal article
    • research article
    • Vol. 38  (3) , 745-748
Abstract
Population surveys demonstrated an inverse relationship between breast cancer incidence rates and the urine estriol ratio, the concentration of estriol relative to the sum of the concentrations of estrone and estradiol. In this study, the urine estriol ratio was evaluated in premenopausal breast cancer patients and control women from Boston and San Francisco [USA]. Although at least 2 yr passed since last use of oral contraceptives, women with a history of oral contraceptive use for 19 mo. or longer excreted estrogen in low concentrations compared to nonusers and so were excluded. Among the remaining 73 cases and 55 controls, the cases had lower estriol ratios and higher estrone and estradiol levels than controls. These differences, which averaged about 10%, were not statistically significant. The hypothesis that a low estriol ratio is a cause of breast cancer is given only minimal support. Among women in their 40''s, the excretion of estrogens is subject to many influences and is difficult to study. The many determinants of estrogen excretion, including age and oral contraceptive use, should be accommodated in the design of future studies of the estriol ratio.