Transcriptional induction of two genes in human cells by beta interferon.
- 1 November 1984
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 81 (21) , 6733-6737
- https://doi.org/10.1073/pnas.81.21.6733
Abstract
The binding of interferons to distinct cell surface receptors leads to the induction of synthesis of several unique polypeptides and their corresponding mRNA (1-6). Two c[complementary]DNA were isolated that are complementary to nuclear RNA whose synthesis is induced from undetectable levels to maximal rates of transcription within 30-60 min after the addition of .beta. interferon to human fibroblasts or to HeLa cells. A single polypeptide can, by binding to a specific plasma membrane receptor, promptly activate the transcription of a defined set of genes.This publication has 36 references indexed in Scilit:
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