The Regulation of the 17-Deoxy Steroids in Man

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Abstract
The 17-deoxy steroids (17-DOS) of the zona fasciculata (ZF) are deoxycorticosterone (DOC), corticosterone (B), 18-hydroxy-deoxycorticosterone (18-OHDOC) and under special conditions, 18-hydroxycorticosterone (18-OHB). In general, studies have been performed to examine the regulation of DOC rather than all the steroids of this pathway. The circadian rhythm of DOC parallels cortisol (1,2). DOC is stimulated by ACTH and completely suppressed by short-term treatment with dexamethasone (2,3,4,5). The renin-angiotensin system (RAS) has some effect on DOC secretion but the results must be interpreted with caution because of early methodology (2,4,6). Short-term infusions with angiotensin II (7) and III (8) had little effect on plasma DOC levels. In a signle study the zona glomerculosa (ZG) stimulation by sodium restriction, and angiotensin II infusion caused slight increases in plasma DOC in a patient with isolated ACTH deficiency but not in normal sub