Chloroquine resistance ofPlasmodium falciparumin West Irian and East Kalimantan

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Abstract
Chloroquine resistance in P. falciparum in West Irian and East Kalimantan [Indonesia] was shown by clinical observation and quantitative parasite counts in 2 patients hospitalized in Tokyo [Japan] where no natural transmission of malaria occurs. The evidence is supported by the determination of plasma chloroquine levels and in vitro sensitivity tests. The highest plasma level of chloroquine in the patient infected in West Irian was 197 ng/ml (4th treatment) and 435 ng/ml (5th treatment), and that in the patient infected in East Kalimantan was 312 ng/ml. Fifty percent inhibition of maturation was obtained in vitro at 0.6 and 0.62 nmol/ml of chloroquine, respectively. Both patients were radically cured by 2 g of sulfadoxine and 100 mg of pyrimethamine given in a single dose.