EVALUATION OF RIGHT ATRIAL PULMONARY ARTERY CONDUITS FOR TRICUSPID ATRESIA - EXPERIMENTAL-STUDY

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  • 1 January 1979
    • journal article
    • research article
    • Vol. 77  (5) , 685-690
Abstract
Blood flow through right atrial-pulmonary artery (RA-PA) conduits was studied. Experiments were designed to evaluate the pumping function of the right atrium, effects of the atrial vs. ventricular pacing site, the necessity of a valve within the conduit and the effect of positive-pressure ventilation on conduit flow. Foxhounds (20) were subjected to silicone patch closure of 90% of the tricuspid valve orifices to create stenosis. Ten dogs successfully underwent RA-PA shunting with a conduit with parallel limbs, 1 containing a prosthetic valve. The proximal main pulmonary artery was ligated to ensure total diversion of blood via the conduit. Valved and nonvalved conduit flow was significantly correlated with right atrial pressure (RAP): r [correlation coefficient] = 0.95, P < 0.05; r = 0.98, P < 0.01, respectively. There was no significant effect of increasing heart rate (P = 0.19), atrial vs. ventricular rhythm (P = 0.28), or the presence of a valve (P = 0.63). Increasing tidal volume caused increasing tidal conduit flow (expiration-inspiration) (r = 1.0, P < 0.01), but mean flow was unaffected. RAP is the most important factor influencing conduit flow. The absence of a valve, ventricular rhythm and tachycardia did not significantly alter flow in this acute experimental model.