Single-Dose Metrifonate for the Treatment of Schistosoma haematobium Infection in an Endemic Area of Zimbabwe

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Abstract
The excretion of Schistosoma haematobium eggs by school children in an endemic area of Zimbabwe was studied for 16 weeks following a single oral dose of 10 mg/kg body weight metrifonate. By 16 weeks, 40.7% of the children had ceased excreting eggs. The mean reduction in egg excretion was 75.1%, but over half the children showed a > 90% reduction. Of the treatment failures, the majority showed less marked or transient reductions in egg excretion, though evidence suggested that 17.5% of the failures may have been due to reinfection.

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