Partial maturation and light chain restriction of Abelson virus‐transformed B cell precursors
- 1 January 1981
- journal article
- research article
- Published by Wiley in European Journal of Immunology
- Vol. 11 (2) , 136-140
- https://doi.org/10.1002/eji.1830110214
Abstract
The induction of partial maturation in an in vitro derived Abelson virus‐transformed murine lymphoid cell subline (ABC‐1/AT1) is described. Pre‐B (cytoplasmic, μ chain‐positive) lymphocytes were induced from presumptive B cell precursors by prostaglandin E1, butyric acid, lipopolysaccharide and interferon. Maturation was independent of alterations in cellular growth rate and could be achieved in the absence of cell division. The AT1 subline was found to be restricted to the expression of a single light chain type (lambda) indicating a possible B cell lineage‐committed precursor as the target for viral transformation.This publication has 14 references indexed in Scilit:
- Evidence that murine pre-B cells synthesise μ heavy chains but no light chainsNature, 1979
- Abelson virus-transformed haematopoietic cell lines with pre-B-cell characteristicsNature, 1979
- Immunoglobulin synthesis by lymphoid cells transformed in vitro by Abelson murine leukemia virusCell, 1979
- Infection of Mouse Bone Marrow Cells with Abelson Murine Leukemia Virus and Establishment of Producer Cell LinesPublished by Springer Nature ,1979
- Preparation and characterization of antibodies to the λ chain variable region (Vλ) of mouse immunoglobulinsEuropean Journal of Immunology, 1978
- Functional macrophage cell lines transformed by abelson leukemia virusCell, 1978
- Abelson virus-transformed lymphocytes: Null cells that modulate H-2Cell, 1977
- Prostaglandin E1, an inducer of erythroid differentiation of friend erythroleukemia cellsExperimental Cell Research, 1977
- Synthesis, surface deposition, and secretion of immunoglobulins by abelson virus-transformed lymphosarcoma cell linesCell, 1975
- Butyric acid, a potent inducer of erythroid differentiation in cultured erythroleukemic cellsCell, 1975