A route to dipeptides containing β-amino-α-hydroxy acid fragments by coupling of N-boc-β-lactams with α-amino esters. Application to the synthesis of (–)-bestatin
- 1 January 1994
- journal article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications
- No. 17,p. 1957-1958
- https://doi.org/10.1039/c39940001957
Abstract
α-Amino esters are smoothly acylated by N-Boc-3-alkoxy-4-alkyl-β-lactams in DMF under the influence of sodium azide, giving a novel dipeptide coupling reaction.Keywords
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