Cytoplasmic inclusion bodies in chronic ulcerative colitis

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Abstract
Summary and Conclusions Twenty-five unselected specimens of chronic ulcerative colitis were studied in order to determine if cytoplasmic inclusion bodies were present. These inclusions were discovered in 56 per cent of the cases. The relationship of chronic ulcerative colitis, neoplastic polyps and cancer of the colon and rectum is mentioned. The chemical and morphologic characteristics of the intracytoplasmic inclusions are reviewed and their possible viral origin and etiologic significance in chronic ulcerative colitis, pseudopolyposis coli, benign neoplastic polyps and cancer of the colon and rectum are discussed. As far as we have been able to ascertain this is the first time cytoplasmic inclusions have been observed in human chronic ulcerative colitis.