Reflections on the total synthesis of natural products: Art, craft, logic, and the chiron approach

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Abstract
An overview is given of various strategies aimed at the total synthesis of natural products, with particular emphasis on some clinically important molecules. Of necessity, total synthesis must also incorporate the elements of absolute stereochemistry, and the ultimate objective of obtaining enantiomerically pure or enriched products. In this regard, the Chiron Approach which capitalizes on the recognition and eventual use of readily available, chiral non-racemic starting materials, has been very successful over the years. A number of examples from the author's laboratory are illustrated and discussed.

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