Cardiovascular Evaluation of a Pressor Amine (Tetrahydrozoline) Showing Hypotensive Properties in Man.,

Publisher Website
Google Scholar
Abstract
Seventeen of 42 patients who received tetrahydrozoline intravenously exhibited an immediate pressor response which lasted an average of 12 minutes. Twenty-five minutes following the initial injection hypotension ensued, lasting an average of 3 hours. The pressor phase was characterized by a decrease in cardiac output, bradycardia and an increase in total peripheral resistance. The hypotensive phase was characterized by no change in cardiac output, less bradycardia than in the pressor phase, and a decrease in peripheral resistance. When tetrahydrozoline was given orally, no pressor response was noted. Twenty-seven of 34 patients exhibited an average reduction of 44 mm Hg systolic pressure, and an average decrease in heart rate of 20 beats per minute. Tolerance usually developed in 7 to 10 weeks.

This publication has 2 references indexed in Scilit: