Hodgkin's Disease

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Abstract
IN 1992, approximately 75 percent of all patients who present with Hodgkin's disease should be cured of their disease. This result will be achieved only with the careful application of appropriate staging techniques and treatment methods.Cell of OriginHodgkin's disease is unusual in that the bulk of the tumor is composed of normal cells within which the malignant Reed–Sternberg cells are found. The cellular origin of the neoplastic cell remains controversial.1 The Reed–Sternberg cells in all the histologic subtypes usually express antigens found on resting or activated lymphocytes. These include CD30 (Ki-1, Hefi-1), CD25 (interleukin-2 receptor), HLA-DR, and CD71 . . .