ADRENOCORTICOTROPIN 52*. Synthesis and Biological Activity of Adrenocorticotropic Peptides with Cystine Bridges
- 12 January 2009
- journal article
- research article
- Published by Wiley in International Journal of Peptide and Protein Research
- Vol. 13 (3) , 346-352
- https://doi.org/10.1111/j.1399-3011.1979.tb01891.x
Abstract
Three analogs of the amino terminal nonadecapeptide of ACTH which incorporate cystine bridges between positions (5, 10), (3, 10), or (2, 10) were synthesized. All of the peptide analogs showed reduced biological activity; the peptide with the 5, 10 cystine bridge was shown to possess significantly higher lipolytic activity in rat fat cells than the peptides with a 3, 10 or 2, 10 cystine bridge.Keywords
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