BOUND RESIDUES OF VETERINARY DRUGS - BIOAVAILABILITY AND TOXICOLOGICAL IMPLICATIONS
- 1 January 1981
- journal article
- research article
- Vol. 12 (3) , 277-289
Abstract
Basic considerations dealing with the biological significance of drug residues in food products of animal origin and safety evaluation were studied. Analytical characteristics clearly distinguished between soluble residues, which depleted relatively fast, and bound material, which was slowly eliminated from edible tissues of target animals. These 2 residual fractions did not have the same bioavailability. Toxicity assessment of bound residues was considered.This publication has 5 references indexed in Scilit:
- Drug metabolites in the toxicologic evaluation of drug safetyToxicology and Applied Pharmacology, 1977
- Metabolic fate of p-toluoyl chloride phenylhydrazone (TCPH) in sheep. The nature of bound residues in erythrocytesJournal of Agricultural and Food Chemistry, 1976
- Alkaline Hydrolysis of Ethyl 5-Amino-2-furoate to α-Ketoglutaramic AcidJournal of Biological Chemistry, 1963
- The Metabolism of 5-Nitro-2-furaldehyde AcetylhydrazoneJournal of Medicinal Chemistry, 1962
- Inhibition of Experimental Drug Allergy by Prior Feeding of the Sensitizing AgentExperimental Biology and Medicine, 1946