14-3-3 proteins in apoptosis
Open Access
- 1 April 2003
- journal article
- review article
- Published by FapUNIFESP (SciELO) in Brazilian Journal of Medical and Biological Research
- Vol. 36 (4) , 403-408
- https://doi.org/10.1590/s0100-879x2003000400001
Abstract
The once obscure members of the 14-3-3 protein family play significant roles in the determination of cell fate. By inhibiting the pro-apoptotic BAD (Bcl-2-antagonist of cell death) and the transcription factor FKHRL-1, 14-3-3 displays important anti-apoptotic characteristics. To date, five points of interaction of 14-3-3 with the apoptotic machinery have been identified. How these interactions are regulated still remains a mystery.Keywords
This publication has 29 references indexed in Scilit:
- Data Mining the Arabidopsis Genome Reveals Fifteen 14-3-3 Genes. Expression Is Demonstrated for Two out of Five Novel GenesPlant Physiology, 2001
- 14-3-3 proteins: regulation of subcellular localization by molecular interferenceCellular Signalling, 2000
- Evolution of the 14-3-3 Protein Family: Does the Large Number of Isoforms in Multicellular Organisms Reflect Functional Specificity?Journal of Molecular Evolution, 2000
- Association of the Cyclin-dependent Kinases and 14-3-3 Sigma Negatively Regulates Cell Cycle ProgressionJournal of Biological Chemistry, 2000
- Modulation of 14-3-3 Protein Interactions with Target Polypeptides by Physical and Metabolic EffectorsPlant and Cell Physiology, 2000
- Structural Analysis of 14-3-3 Phosphopeptide Complexes Identifies a Dual Role for the Nuclear Export Signal of 14-3-3 in Ligand BindingMolecular Cell, 1999
- Protein kinase B/Akt is activated by polyomavirus middle-T antigen via a phosphatidylinositol 3-kinase-dependent mechanismOncogene, 1998
- The Structural Basis for 14-3-3:Phosphopeptide Binding SpecificityCell, 1997
- 14-3-3 PROTEINS AND SIGNAL TRANSDUCTIONAnnual Review of Plant Biology, 1996
- Human 14‐3‐3 Protein: Radioimmunoassay, Tissue Distribution, and Cerebrospinal Fluid Levels in Patients with Neurological DisordersJournal of Neurochemistry, 1982