Role of modelling and simulation in Phase I drug development

This publication has 21 references indexed in Scilit:

• Simulation of Clinical Trials
  Annual Review of Pharmacology and Toxicology, 2000
• A mechanism‐based pharmacokinetic‐enzyme model for cyclophosphamide autoinduction in breast cancer patients
  British Journal of Clinical Pharmacology, 1999
• Modeling of Pharmacokinetic/Pharmacodynamic (PK/PD) Relationships: Concepts and Perspectives
  Pharmaceutical Research, 1999
• The pharmacokinetic modelling of GI198745 (dutasteride), a compound with parallel linear and nonlinear elimination
  British Journal of Clinical Pharmacology, 1999
• A model for the turnover of dihydrotestosterone in the presence of the irreversible 5α-reductase inhibitors GI198745 and finasteride
  Clinical Pharmacology & Therapeutics, 1998
• Relevance of the Application of Pharmacokinetic-Pharmacodynamic Modelling Concepts in Drug Development
  Clinical Pharmacokinetics, 1997
• Recombinat hormones: Structure-function relationship of recombinant follicle stimulating hormone (Puregon^®)
  Molecular Human Reproduction, 1996
• Physiologically based pharmacokinetic modeling as a tool for drug development
  Journal of Pharmacokinetics and Biopharmaceutics, 1995
• The kinetics of the auto-induction of ifosfamide metabolism during continuous infusion
  Cancer Chemotherapy and Pharmacology, 1995
• A mathematical model for dynamics of cardiovascular drug action: Application to intravenous dihydropyridines in healthy volunteers
  Journal of Pharmacokinetics and Biopharmaceutics, 1993