The activation of phosphoglucomutase by metal ions

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Abstract
The greatest activity of phosphoglucomutase from muscle was found to occur only in the simultaneous presence of 3 activators, hexosediphosphate, Mg++, and a 2d metal, Al+++, Cr+++, Pb++, Fe+++, or Ce+++; some other metals also showed smaller activity. In this system Mg++ could not be replaced by Mn++ or Co++. The max. activity was some 10 times that previously observed with Mn++ as the only activator. Of all the "2d metals" only Cr+++ showed any activity in the absence of Mg++, and that only at relatively high concns. If the "2d metal" activation had any physiological importance, then Cr+++ and Mg+++ were the metals concerned.

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