Notes on the Toxicology of Cobalt Metal
Open Access
- 1 April 1950
- journal article
- research article
- Published by BMJ in Occupational and Environmental Medicine
- Vol. 7 (2) , 76-78
- https://doi.org/10.1136/oem.7.2.76
Abstract
Rats in series of 6 received Co by intratracheal injn. of the metallic powder in saline, by inhalation of Co dust, and by intraperit. injn. Pulmonary edema and hemorrhages from severe capillary damage resulted in the lungs and usually proved fatal. In the peritoneal cavity it led to ascites and oligemic shock. It seems that the local effect on capillaries results from the solubility of Co in tissue fluids, and that the damage is done during the process of solution, which involves attachment of Co metal to protein. Co is 500 times more soluble in plasma than in saline.Keywords
This publication has 4 references indexed in Scilit:
- Cobalt and the Dust Environment of the Cemented Tungsten Carbide IndustryPublic Health Reports (1896-1970), 1949
- Manganese PneumonitisOccupational and Environmental Medicine, 1946
- The absorption and excretion of ‘minor’ elements by manBiochemical Journal, 1941