7S Class-Restricted Hapten-Specific Paralysis by Injection of Thymus-Independent Hapten-Carrier Conjugate
Open Access
- 1 November 1975
- journal article
- Published by Oxford University Press (OUP) in The Journal of Immunology
- Vol. 115 (5) , 1239-1242
- https://doi.org/10.4049/jimmunol.115.5.1239
Abstract
The shift from IgM anti-hapten antibody production to IgG anti-hapten antibody production, subsequent to challenge with a T-dependent conjugate, is inhibited in mice by preimmunization with the T-independent DNP-LE conjugate. The results suggest that DNP on levan triggers off 19S T-independent anti-hapten precursors and paralyzes 7S T-dependent anti-hapten precursors.Keywords
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