Synthesis and hypoglycemic activity of 4-substituted 3-mercaptopicolinic acids
- 1 December 1977
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Medicinal Chemistry
- Vol. 20 (12) , 1572-1577
- https://doi.org/10.1021/jm00222a007
Abstract
3-Mercapto-4-methylpicolinic acid was 1 of very few compounds derived from 3-mercaptopicolinic acid (3-MPA) to have hypoglycemic activity. In an effort to find compounds with greater potency than 3-MPA, several 4-substituted 3-mercaptopicolinic acids (4-OMe, OC6H5, SMe, SH, Cl, NH2, Et) were prepared and tested in 48 h fasted rats. None was hypoglycemic in this test system after oral dosing of 150 mg/kg.This publication has 7 references indexed in Scilit:
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