A Novel Three-Component One-Pot Pyrimidine Synthesis Based upon a Coupling−Isomerization Sequence
- 1 June 2000
- journal article
- Published by American Chemical Society (ACS) in Organic Letters
- Vol. 2 (13) , 1967-1970
- https://doi.org/10.1021/ol006046e
Abstract
[reaction: see text] 2,4,6-Tri(hetero)aryl-substituted pyrimidines can be readily synthesized in a three-component one-pot process based upon a coupling-isomerization sequence of an electron-poor (hetero)aryl halide and a terminal propargyl alcohol subsequently followed by a cyclocondensation with amidinium salts.Keywords
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